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antioxidant effects of sulforaphane in human hepg2 cells

Antioxidant effects of sulforaphane in human HepG2 cells ... Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells.

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥20 μM).

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes ... Source: Food and chemical toxicology 2019 v.128 pp. 129-136 ISSN: 0278-6915 Subject: DNA damage, antineoplastic activity, antioxidant activity, cell death, cell viability, clinical trials, enzymes, glutathione, hepatocytes, hepatoma, human cell lines ...

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Antioxidant effects of sulforaphane in human HepG2 cells ...

T D ACCEPTED MANUSCRIPT 1 Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes Peng Liu 1, Wei Wang , Jonathan Tang 1, Richard P. Bowater2, Yongping Bao 1,* 1 Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, Norfolk, United Kingdom. 2 School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk,

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Antioxidant effects of sulforaphane in human HepG2 cells ...

PDF | Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the... | Find, read and cite all the research ...

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects...

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥20 µM). It also activated the nuclear factor (erythroid ...

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocyte (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥ 20 µM). It also activated the nuclear factor (erythroid ...

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes. by Peng Liu, Wei Wang, Jonathan Tang, Richard P Bowater, Yongping Bao. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. Read more related scholarly scientific articles and abstracts.

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocyte (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥ 20 µM).

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥20 μM).

Leave a Message

Antioxidant effects of sulforaphane in human HepG2 cells ...

Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes ... Source: Food and chemical toxicology 2019 v.128 pp. 129-136 ISSN: 0278-6915 Subject: DNA damage, antineoplastic activity, antioxidant activity, cell death, cell viability, clinical trials, enzymes, glutathione, hepatocytes, hepatoma, human cell lines ...

Leave a Message

Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells.

Leave a Message

Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects...

Leave a Message

Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocyte (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥ 20 µM).

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Article “Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes” Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, and Sparking, linking science and technology information which hitherto ...

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Chemopreventive Activities of Sulforaphane and Its ...

Here, three metabolites derived from SFN were studied, known as sulforaphane glutathione, sulforaphane cysteine and sulforaphane-N-acetylcysteine. Their effects on cell viability, DNA damage, tumorigenicity, cell migration and adhesion were measured in human hepatoma HepG2 cells, and their anti-angiogenetic effects were determined in a 3D co ...

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In vitro assessment of the indirect antioxidant activity ...

Owing to sulforaphane presence, a dietary consumption of Brassicaceae prevents chronic diseases. This hormetic compound induces adaptive stress response at subtoxic doses, while doses that exceed the cellular defence are toxic. In HepG2, Caco-2 and Vero cells, we investigated the sulforaphane (SFN) …

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Dual Action of Sulforaphane in the Regulation of ...

We have previously demonstrated that sulforaphane is a potent inducer for thioredoxin reductase in HepG2 and MCF-7 cells (Zhang et al. Carcinogenesis 2003, 24, 497−503; Wang et al. J. Agric. Food Chem. 2005, 53, 1417−1421). In this study, we have shown that sulforaphane is not only an inducer for thioredoxin reductase but also an inducer for its substrate, thioredoxin in HepG2, and ...

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Differential effects of sulforaphane on histone ...

Scope: Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables such as broccoli. The ability of SFN to inhibit histone deacetylase (HDAC) enzymes may be one mechanism by which it acts as a chemoprevention agent. The ability of a chemopreventive agent to specifically cause cytotoxicity in cancer and not normal cells is an important factor in determining its safety and ...

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Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells.

Leave a Message

Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects of SFN were measured in both human hepatocytes (HHL5) and hepatoma (HepG2) cells. Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (≥20 μM).

Leave a Message

Antioxidant effects of sulforaphane in human HepG2 cells ...

Sulforaphane (SFN) has shown anti-cancer effects in cellular and animal studies but its effectiveness has been limited in human studies. Here, the effects...

Leave a Message

Antioxidant effects of sulforaphane in human HepG2 cells ...

Article “Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes” Detailed information of the J-GLOBAL is a service based on the concept of Linking, Expanding, and Sparking, linking science and technology information which hitherto ...

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Effect of sulforaphane on metallothionein expression and ...

Abstract. The molecular mechanism of sulforaphane on the induction of metallothionein ( MT) genes in HepG2 cells and the antiproliferative effects of sulforaphane were investigated in this study.Treatment of the cells with sulforaphane at non-toxicity concentration (0–20 µM) resulted in coordinate increases in the induction of MT-I and MT-II mRNA, followed by corresponding increases in MT ...

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Mechanism of Action of Sulforaphane: Inhibition of p38 ...

Exposure of sulforaphane to HepG2 cells increased heme oxygenase-1 (HO-1) expression by activating antioxidant response element (ARE) through induction of Nrf2 and suppression of Kelch-like ECH-associated protein 1 (Keap1). Using human HO-1 promoter reporter plasmids and ChIP assay, we have identified that sulforaphane transcriptionally activated the upstream ARE-rich enhancer region, located ...

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Metabolism and antiproliferative effects of sulforaphane ...

The purpose of this work was to study the absorption and metabolism of sulforaphane (SFN) from broccoli sprouts, their major glucosinolate glucoraphanin and its hydrolysis product SFN. This was done by monitoring SFN’s main metabolites, i.e. SFN, SFN-glutathione and SFN-cysteine, in two different cell models of absorption and metabolism (Caco-2 colorectal carcinoma cells and HepG2 ...

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Dual Action of Sulforaphane in the Regulation of ...

We have previously demonstrated that sulforaphane is a potent inducer for thioredoxin reductase in HepG2 and MCF-7 cells (Zhang et al. Carcinogenesis 2003, 24, 497−503; Wang et al. J. Agric. Food Chem. 2005, 53, 1417−1421). In this study, we have shown that sulforaphane is not only an inducer for thioredoxin reductase but also an inducer for its substrate, thioredoxin in HepG2, and ...

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Antioxidants | Free Full-Text | Effects of Cooking and ...

The cytoprotective effect against oxidative damage induced by H2O2 was studied using hepatocellular carcinoma (HepG2) cells. Anti-proliferative effects were assessed in MCF-7 and MDA-MB-231 breast cancer cells. L-sulforaphane in broccoli extracts was quantified using high-performance liquid chromatography (HPLC).

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ARE Reporter Cell Line (Nrf2 antioxidant pathway)

Effects of Amaranthus cruentus L. on aflatoxin B1- and oxidative stress-induced DNA damage in human liver (HepG2) cells (2018) 9. Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships (2018)

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